Independent Component Analysis of the Effect of L-dopa on fMRI of Language Processing
dc.contributor.author | Kim, Namhee | |
dc.contributor.author | Goel, Prem K. | |
dc.contributor.author | Tivarus, Madalina E. | |
dc.contributor.author | Hillier, Ashleigh | |
dc.contributor.author | Beversdorf, David Q. | |
dc.date.accessioned | 2014-03-05T20:15:35Z | |
dc.date.accessioned | 2020-02-19T21:18:39Z | |
dc.date.available | 2014-03-05T20:15:35Z | |
dc.date.available | 2020-02-19T21:18:39Z | |
dc.date.issued | 2010-08-17 | |
dc.description | Ashleigh Hillier serves on the faculty at UMass Lowell in the Department of Psychology. | en_US |
dc.description.abstract | L-dopa, which is a precursor for dopamine, acts to amplify strong signals, and dampen weak signals as suggested by previous studies. The effect of L-dopa has been demonstrated in language studies, suggesting restriction of the semantic network. In this study, we aimed to examine the effect of L-dopa on language processing with fMRI using Independent Component Analysis (ICA). Two types of language tasks (phonological and semantic categorization tasks) were tested under two drug conditions (placebo and L-dopa) in 16 healthy subjects. Probabilistic ICA (PICA), part of FSL, was implemented to generate Independent Components (IC) for each subject for the four conditions and the ICs were classified into task-relevant source groups by a correlation threshold criterion. Our key findings include: (i) The highly task-relevant brain regions including the Left Inferior Frontal Gyrus (LIFG), Left Fusiform Gyrus (LFUS), Left Parietal lobe (LPAR) and Superior Temporal Gyrus (STG) were activated with both L-dopa and placebo for both tasks, and (ii) as compared to placebo, L-dopa was associated with increased activity in posterior regions, including the superior temporal area (BA 22), and decreased activity in the thalamus (pulvinar) and inferior frontal gyrus (BA 11/47) for both tasks. These results raise the possibility that L-dopa may exert an indirect effect on posterior regions mediated by the thalamus (pulvinar). | en_US |
dc.identifier.citation | Kim, N., Goel, P. K., Tivarus, M. E., Hillier, A., Beversdorf, D. Q. (2010, August 17). Independent Component Analysis of the Effect of L-dopa on fMRI of Language Processing. PloS One 5(8), 1-10. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011933 | en_US |
dc.identifier.other | 10.1371/journal.pone.0011933 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12517/195 | |
dc.language.iso | en_US | en_US |
dc.publisher | PLoS ONE | en_US |
dc.title | Independent Component Analysis of the Effect of L-dopa on fMRI of Language Processing | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- PlosOne_2010_Idependent-Component-Analysis.pdf
- Size:
- 2.15 MB
- Format:
- Adobe Portable Document Format
- Description: