Kennedy College of Sciences
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Item Open Access 2.32 THz quantum cascade laser frequencylocked to the harmonic of a microwave synthesizer source(Optics Express, 2012-11-29) Danylov, Andriy A.; Light, Alexander R.; Waldman, Jerry; Erickson, Neal R.; Qian, Xifeng; Goodhue, William D.Item Open Access Characterization of bending loss in hollow flexible terahertz waveguides(Optics Express, 2012-08-13) Doradla, Pallavi; Joseph, Cecil S.; Kumar, Jayant; Giles, Robert H.Item Open Access Collective phenomena in photonic, plasmonic and hybrid structures(Optics Express, 2011-10-24) Boriskina, Svetlana V.; Povinelli, Michelle; Astratov, Vasily N.; Zayats, Anatoly V.; Podolskiy, Viktor A.Item Open Access Compensation of loss in propagating surface plasmon polariton by gain in adjacent dielectric medium(Optics Express, 2008-01-21) Noginov, M. A.; Podolskiy, Viktor A.; Zhu, G.; Mayy, M.; Bahoura, M.; Adegoke, J. A.; Ritzo, B. A.; Reynolds, K.Item Open Access Dynamical localization in microdisk lasers(Optics Express, 2005-07-25) Fang, Wei; Cao, Hui; Podolskiy, Viktor A.; Narimanov, EvgeniiItem Open Access Enhanced bandwidth and reduced dispersion through stacking multiple optical metamaterials(Optics Express, 2011-08-01) Escarra, Matthew D.; Thongrattanasiri, Sukosin; Charles, William O.; Hoffman, Anthony J.; Podolskiy, Viktor A.; Gmachl, ClaireItem Open Access Enhanced immuno-detection of shed extracellular domain of HER-2/neu(Health, 2009-12-31) Chourb, Sinang; Mackness, Brian C.; Farris, Leslie R.; McDonald, Melisenda J.HER-2/neu oncogene is over-expressed and amplified in patients associated with metastatic breast cancer. An increased level (>15 ng/mL) in the shed extracellular domain (sECD-HER 2/neu) is indicative of the potential presence and as-sociated progression of this disease. A fluo-rescent ELISA incorporating the newly devel-oped ALYGNSA antibody-orientation system revealed a 10-fold increase in sensitivity (?0.63 ng/mL) of sECD-HER 2/neu when compared to a control standard ELISA kit (?7.5 ng/mL). This enhanced mode of detection has the potential to not only address breast and other cancers per se but also permit an in depth evaluation of “shed extracellular domains”, in general, and the role of these “proteolytic derived factors” in physiological signalling at normal levels.Item Open Access Frequency stabilization of a single mode terahertz quantum cascade laser to the kilohertz level(Optics Express, 2009-04-27) Danylov, Andriy A.; Goyette, Thomas M.; Waldman, Jerry; Coulombe, Michael J.; Gatesman, Andrew J.; Giles, Robert H.; Goodhue, William D.; Qian, Xifeng; Nixon, William E.Item Open Access Improved detection of the MUC1 cancer antigen CA 15-3 by ALYGNSA fluorimmunoassay(Health, 2011-08-11) Chourb, Sinang; Mackness, Brian C.; Farris, Leslie R.; McDonald, Melisenda J.Breast cancer is the second leading cause of cancer-related deaths in women worldwide; a prime cancer biomarker to aid in the diagnosis, directed treatment, clinical management, and reoccurrence of this cancer is a MUC1 peptide fragment: cancer antigen 15-3 (CA 15-3). Herein, an immuno-fluorescence assay for CA 15-3 was developed; this ALYGNSA system consists of a protein biolinker (Protein G’) adsorbed onto Poly (methyl methacrylate) (PMMA). The unique interaction of Protein G’ with PMMA, a thermo- plastic polymer has been demonstrated to im- prove human IgG capture antibody alignment/ orientation and result in greater assay sensi- tivity. Indeed a previous report (HEALTH 1 325 - 329, 2009) on the shed extracellular domain of HER-2/neu revealed a 10-fold increase in sensi- tivity of the ALYGSNA assay over a control ELISA assay. Results from this ALYGNSA assay study revealed that a 16-fold increase in dete- ction (?0.94 U/mL) of CA 15-3 was found in comparison to a commercial control ELISA kit (?15 U/mL). In conclusion, this enhanced sen- sitivity of the ALYGNSA assay for CA 15-3, may provide insights into the role/function of this biomarker in normal, as well as, breast cancer and other epithelial cancers.Item Open Access Multiscale beam evolution and shaping in corrugated plasmonic systems(Optics Express, 2011-05-09) Thongrattanasiri, S.; Adams, D. C.; Wasserman, Daniel; Podolskiy, Viktor A.Item Open Access OPD measurement and dispersion reduction in a monolithic interferometer(Optics Express, 2010-08-02) Hicks, Brian; Cook, Timothy; Lane, Benjamin; Chakrabarti, SupriyaItem Open Access Plasmon modes and negative refraction in metal nanowire composites(Optics Express, 2003-04-07) Podolskiy, Viktor A.; Sarychev, Andrey K.; Shalaev, Vladimir M.Item Open Access A Reference Proteomic Database of Lactobacillus plantarum CMCC-P0002(PLoS ONE, 2011-10-05) Zhu, Li; Hu, Wei; Liu, Datao; Tian, Wanhong; Yu, Gang; Liu, Xiankai; Wang, Jie; Feng, Erling; Zhang, Xuemin; Chen, Bei; Zeng, Ming; Wang, HengliangLactobacillus plantarum is a widespread probiotic bacteria found in many fermented food products. In this study, the whole-cell proteins and secretory proteins of L. plantarum were separated by two-dimensional electrophoresis method. A total of 434 proteins were identified by tandem mass spectrometry, including a plasmid-encoded hypothetical protein pLP9000_05. The information of first 20 highest abundance proteins was listed for the further genetic manipulation of L. plantarum, such as construction of high-level expressions system. Furthermore, the first interaction map of L. plantarum was established by Blue-Native/SDS-PAGE technique. A heterodimeric complex composed of maltose phosphorylase Map3 and Map2, and two homodimeric complexes composed of Map3 and Map2 respectively, were identified at the same time, indicating the important roles of these proteins. These findings provided valuable information for the further proteomic researches of L. plantarum.Item Open Access Sub-diffraction negative and positive index modes in mid-infrared waveguides(Optics Express, 2008-10-13) Hoffman, Anthony J.; Podolskiy, Viktor A.; Sivco, Deborah L.; Gmachl, ClaireItem Open Access Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter(Optics Express, 2010-07-16) Danylov, Andriy A.; Goyette, Thomas M.; Waldman, Jerry; Coulombe, Michael J.; Gatesman, Andrew J.; Giles, Robert H.; Qian, Xifeng; Chandrayan, Neelima; Vangala, Shivashankar; Termkoa, Krongtip; Goodhue, William D.; Nixon, William E.Item Open Access Terahertz sideband-tuned quantum cascade laser radiation(Optics Express, 2008-04-14) Danylov, Andriy A.; Waldman, Jerry; Goyette, Thomas M.; Gatesman, Andrew J.; Giles, Robert H.; Li, Jin; Goodhue, William D.; Linden, Kurt J.; Nixon, William E.Item Open Access Toxic Metals in Aquatic Ecosystems:A Microbiological Perspective(Environmental health perspectives, 1995-02) Ford, Timothy; Ryan, DavidMicrobe-metal interactions in aquatic environments and their exact role in transport and transformations of toxic metals are poorly understood. This paper will briefly review our understanding of these interactions. Ongoing research in Lake Chapala, Mexico, the major water source for the City of Guadalajara, provides an opportunity to study the microbiological aspects of metal-cycling in the water column. Constant resuspension of sediments provides a microbiologically rich aggregate-based system. Data indicate that toxic metals are concentrated on aggregate material and bioaccumulate in the food chain. A provisional model is presented for involvement of microbial aggregates in metal-cycling in Lake Chapala.Item Open Access Using metal nanostructures to form hydrocarbons from carbon dioxide, water and sunlight(AIP Advances, 2011-10-21) Wang, Cong; Shen, Mengyan; Huo, Haibin; Ren, Haizhou; Johnson, MichaelBased on experimental results, we propose a mechanism that allows the use of metal nanostructures to synthesize hydrocarbons and carbohydrates from carbon dioxide, water and sunlight. When sunlight impinges on cobaltnanostructures in a glass chamber, its intensity is greatly enhanced around the tips of the nanostructures through surface plasmonexcitations focusing effect, and it then photodissociates the water and carbon dioxide molecules through enhanced photon absorptions of ions around the tips of the nanostructures. The photodissociated molecules in excited states remain on the cobaltnanostructuresurfaces and various hydrocarbons and carbohydrates then will be formed around the surfaces at temperatures much lower than 100 oC.